Award details

Further development of an AAV vector production system exploiting novel AAV/HSV hybrids

Reference	E20016
Principal Investigator / Supervisor	Dr R Coffin
Co-Investigators / Co-Supervisors	Dr Matthew Booth, Professor Adrian Thrasher
Institution	University College London
Department	Immunology and Molecular Pathology
Funding type	Research
Value (£)	160,357
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

This project aims to further develop production technology for AAV vectors through the use of HSV/AAV hybrids rather than the more commonly used adenovirus. This builds on previous BBSRC funded work where considerable progress was made. Clinical trials using AAV vectors are promising in e.g. haemophilia, but effective and scalable production technology is lacking. The aim of the project is to develop a robust and scalable production system not requiring transfection as is currently the case. We have generated HSV-based production systems overcoming various technical hurdles which now require further optimisation and development before up-scaling as required if HSV produced AAV vectors are to be used in pre-clinical and clinical studies.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Engineering & Biological System Committee (EBL) [2000-2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search