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The use of temperature to modulate mesenchymal stem cell differentiation
Reference
E19839
Principal Investigator / Supervisor
Dr Andrew Scutt
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Materials Science and Engineering
Funding type
Research
Value (£)
170,946
Status
Completed
Type
Research Grant
Start date
01/12/2003
End date
30/11/2006
Duration
36 months
Abstract
Adult mesenchymal stem cells (MSC) are pluripotent and can be used to engineer tissues such as bone, cartilage or tendon which can then be used in patients needing transplants of these tissues. MSC are only available in limited numbers and during amplification in vitro tend to differentiate and lose their stem cell-like properties. We have previously shown that culturing MSC at a reduced temperature inhibited their osteoblastic differentiation and extended their lifetime in culture. We wish now to determine exactly how long their lifetime is extended and whether their pluripotency is retained.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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