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Interrogation of bioengineered vascular tissue by biophysical methods
Reference
E19397
Principal Investigator / Supervisor
Professor Jian Lu
Co-Investigators /
Co-Supervisors
Dr John Garland
,
Professor Anthony Heagerty
Institution
The University of Manchester
Department
Physics and Astronomy
Funding type
Research
Value (£)
261,260
Status
Completed
Type
Research Grant
Start date
06/10/2003
End date
05/12/2005
Duration
26 months
Abstract
Polymer scaffolds are often used in bioreactors to guide tissue growth, but the effects of surface chemistry, surface topological features and the deposition of ECM proteins on the formation of complex tissues remain to be an unknown and largely unexplored area. We propose to examine these effects from PLGA scaffolds with controlled surface chemistry and topology using a combined physical and biological characterisation of responses of adult VSMC cell growth in first 48 hr, which is crucial for inductive cell responses and tissue structuring. We will translate the new findings from the 2D interfaces into 3D scaffolds used in bioreactors in which we have demonstrated formation of prototype vessels.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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