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Enhanced protein-protein docking using a multi- resolution approach - application to multi-domain proteins
Reference
E19386
Principal Investigator / Supervisor
Professor Michael Sternberg
Co-Investigators /
Co-Supervisors
Professor Guang-Zhong Yang
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
200,152
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/10/2006
Duration
36 months
Abstract
The aim is to develop an enhanced algorithm to predict the docked structure of two proteins or two domains. We will develop: (1) a novel and fast procedure to identify putative complexes with shape complementarity using implicit (i.e. analytic) surfaces at different resolutions; (2) a fast, multi-resolution, accurate approach to model electrostatic interactions considering both components as low dielectric media within solvent using finite difference Poisson-Boltzmann calculations and (3) an approach to evaluate both if two protein domains are closely docked and if so to predict their structure. We will disseminate the methodology to the community.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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