Award details

Construction and evaluation of Lux/GFP+ reporter bacteria to demonstrate intracellular activity of anti-cancer drugs

Reference	E19334
Principal Investigator / Supervisor	Professor Vyvyan Salisbury
Co-Investigators / Co-Supervisors	Dr Habib Alloush, Dr Shona Nelson, Dr Ann Smith
Institution	University of the West of England
Department	Faculty of Health and Applied Sciences
Funding type	Research
Value (£)	239,488
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Bacteria expressing lux genes are used to study real time pharmacodynamics of antimicrobial agents. We aim to extend this elegant reporter gene technology and construct bacteria carrying a dual GFP/lux reporter system. GFP genes will be inserted downstream of stress-responsive promoters in the bacteria to increase assay speed and sensitivity.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E19331 Construction and evaluation of Lux/GFP+ reporter bacteria to demonstrate intracellular activity of anti-cancer drugs

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