Award details

The biology of drug targeting: Predictive mathematical modelling of drug impact in complex and dynamic cell populations

Reference	E19305
Principal Investigator / Supervisor	Professor Michael Chappell
Co-Investigators / Co-Supervisors	Professor Keith Godfrey
Institution	University of Warwick
Department	Sch of Engineering
Funding type	Research
Value (£)	134,016
Status	Completed
Type	Research Grant
Start date	01/02/2004
End date	30/04/2007
Duration	39 months

Abstract

We aim to develop, within a two-site collaboration, integrated mathematical models for pharmacokinetics and pharmacodynamics that demand innovative biotechnological and mathematical solutions. The project addresses single cell drug responses in heterogenous and dynamic cell populations. The work has widespread application in predictive biomedicine and in silico drug screening. We will focus on drug targeting and its link with perturbation of the mammalian cell cycle using novel live- cell behaviour and protein-tracking methods together with mathematical models. The biotechnology will support the derivation and validation of non-linear models that present significant challenges for structural identifiability. (Joint with grant number 19292).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E19292 The biology of drug targeting: Predictive mathematical modelling of drug impact in complex and dynamic cell populations

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