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Continuous scalable medium pressure homogeniser to produce nanosized biopharmaceutical formulations

Reference	E18992
Principal Investigator / Supervisor	Professor Oya Alpar
Co-Investigators / Co-Supervisors	Professor Stephen Brocchini, Ms Claire Martin, Professor Nigel Slater
Institution	University College London
Department	Centre for Drug Delivery Research
Funding type	Research
Value (£)	293,656
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2006
Duration	36 months

Abstract

A continuous medium speed homogenisation process will be developed to prepare sterile, nanoparticles containing biopharmaceutical molecules. The overall aim is towards a scalable process for reproducible production of monodispersed nanoparticle delivery systems for bio-active DNA and protein- based agent. Optimisation of particle size and yield, loading and retention of drug bioactivity and replacement of chlorinated solvents during the process will be performed and effects of pressure on these parameters investigated. Once optimal conditions are determined, the project will focus on the physicochemical and biological evaluation of two clinically relevant biopharmaceutical agents.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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