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Novel racemases for enzymatic dynamic kinetic resolution
Reference
E18971
Principal Investigator / Supervisor
Professor Nicholas Turner
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
138,216
Status
Completed
Type
Research Grant
Start date
01/06/2003
End date
31/08/2005
Duration
27 months
Abstract
The principal aim of this proposal is to develop novel racemases for use in situ with existing enantioselective amidohydrolases for the dynamic kinetic resolution of important chiral molecules such as natural and unnatural amino acids. We initially propose to apply a powerful in vivo selection which we have developed, to identify novel enzymes displaying N-acylamino acid racemase (NAAAR) activity. This has been observed previously as a minor property of enolase superfamily enzymes. We will specifically select for variants with increased NAAAR activity, appropriate for industrial application with L or D-amino acid specific hydrolases. Ultimately the approach will be extended to the production of chiral amines and alcohols.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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