Award details

Experimental (micro-fluids) & theoretical (modelling) engineering of electro-mechanically active cardiac cell cultures

Reference	E18561
Principal Investigator / Supervisor	Dr Peter Kohl
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Physiology Anatomy and Genetics
Funding type	Research
Value (£)	322,072
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	30/04/2006
Duration	36 months

Abstract

This study aims at developing and using improved in vitro models that are simple, reproducible and representative for cardiac tissue. These models will address cardiac electro-mechanical function in 2D and represent key aspects of structural organisation and physical environment of normal and injured myocardium. Cardiomycote attachment, orientation and shape are controlled independently by micro-fluidic patterning techniques. This technique has the advantage that it can be applied to soft substrates, so that the mechanical environment of cells can also be controlled. A set of matching mathematical (in silico) models will be developed to aid experimental design, data integration, interpretation, and extrapolation from in vitro and to in vivo.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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