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Development of high resolution rapid scanning ion conductance microscopy for liver cell studies

Reference	E18541
Principal Investigator / Supervisor	Professor Yuri Korchev
Co-Investigators / Co-Supervisors	Professor David Klenerman
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	126,160
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/10/2004
Duration	18 months

Abstract

Scanning ion conductance microscopy (SICM) has been demonstrated by us to have wide application for live cell imaging, functional mapping and high resolution patch clamping. We seek funds to significantly improve the speed and resolution of imaging by redesigning the microscope and introducing faster feedback control and novel scanning procedures. This will enable us to follow membrane dynamics and sub-cellular features such as microvilli and caveolae in the cell membrane and fellow the cell response to stimuli, in real-time. We will also explore if it is possible to directly image proteins and ion channels. The instrument will have wide application not only in the biological sciences but also the physical sciences for the imaging of the solid- liquid interface and polymer surfaces.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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