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A patterned surface for the combined transplantation of keratinocytes and melanocytes for treatment of vitiligo
Reference
E18528
Principal Investigator / Supervisor
Professor Sheila MacNeil
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Materials Science and Engineering
Funding type
Research
Value (£)
293,768
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
01/04/2006
Duration
36 months
Abstract
The restoration of normal skin pigmentation is the key aim in surgical treatment of vitiligo. One of the more successful strategies to date involves a transplantation of autologous melanocytes and keratinocytes to the depigmented area, the keratinocytes to achieve rapid epithelial cover and the melanocytes to restore pigmentation. However, co-culture of these two cell types is problematic as recent results show that high concentrations of keratinocytes adversely affect both melanocyte number and pigmentary function. In this project we intend to develop a chemically patterned support that maintains a physical separation between the two cell types enabling transfer of both cell types of the patient simultaneously to achieve good wound healing and pigmentation.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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