Award details

Tissue Bioreactor Science (TIBS)

Reference	E18398
Principal Investigator / Supervisor	Professor Robert Brown
Co-Investigators / Co-Supervisors	Professor Gordon Blunn, Professor David Delpy, Professor Geoffrey Goldspink, Professor Jonathan Knowles, Professor Alexander MacRobert, Professor Vivek Mudera
Institution	University College London
Department	Institute of Orthopaedics
Funding type	Research
Value (£)	849,520
Status	Completed
Type	Research Grant
Start date	16/06/2003
End date	15/11/2008
Duration	65 months

Abstract

The TIBS tissue engineering programme aims to establish a scientific basis (platform technologies) for the design and operation of advanced mechanical tissue bioreactors, growing neotissues as mechanical units. The exemplar target tissue is a ligament-bone construct. The 4 project consortium (part of a wider London collaboration: ALTEC) comprises UCL (lead), QMC and IC. Existing, novel mechano-bioreactors, based on pioneering work in cytomechanical regulation, will be used to solve the twin problems of nutrient perfusion and collagen deposition and organisation. These will establish basic mechanisms and the role of (i) COMBINATION cues of mechanical loading and growth factors; (ii) background factors - existing matrix and gravity; (iii) novel (hard and soft) composite cell support biomaterials; (iv) use of rational cell and matrix control cues for the new design platforms to test neo-tissue growth (a) long term (b) as integrated 2-phase units (ie scientifically rational advanced bioreactors). (Joint with grants 18399 and 18400).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Industrial Biotechnology, Regenerative Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E18399 Tissue Bioreactor Science (TIBS)

E18400 Tissue Bioreactor Science (TIBS)

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search