Award details

Stochastic models for yeast prion propagation

Reference	E18382
Principal Investigator / Supervisor	Professor Emeritus Mick Tuite
Co-Investigators / Co-Supervisors	Professor Byron John Treharne Morgan, Professor Martin Ridout
Institution	University of Kent
Department	Sch of Biosciences
Funding type	Research
Value (£)	275,336
Status	Completed
Type	Research Grant
Start date	01/01/2003
End date	31/08/2006
Duration	44 months

Abstract

The mechanism by which the yeast (PSI plus) prion determinant is propagated and transmitted to daughter cells will be modelled using data from novel laboratory-based experiments. These experiments will exploit the fact that guanidine hydrochloride (GdnHCI) can be used to reversibly inhibit prion propagation in yeast leading to prion elimination. Our models will be extended to fully account for cell death and mother-daughter asymmetry during cell division. The effects of genetic and environmental factors on prion propagation will be assessed and modelled. The approach will be extended to two other yeast prions. (RNQ plus) and (URA3) and to other chemical agents that cure yeast prions. By developing appropriate statistical models, we will provide linked information on the underlying molecular process by which prions are propagated in yeast and mammalian cells.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search