Award details

Comprehensive analysis of the yeast metabolome using NMR

Reference	E18367
Principal Investigator / Supervisor	Professor Stephen Oliver
Co-Investigators / Co-Supervisors	Professor Richard Reece
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	209,184
Status	Completed
Type	Research Grant
Start date	15/05/2003
End date	14/05/2006
Duration	36 months

Abstract

Functional genomics requires comprehensive methods for analysing the phenotypes that result from gene deletion. These include methods for measuring the levels of mRNAs (transcriptome), proteins (proteome) and metabolites (metabolome). The relationship between gene expression and metabolite profile is complex. However, we have shown recently how metabolite profiles, determined by NMR, could be used to elucidate the function of unknown genes in yeast by comparing the metabolite profiles of strains deleted for these unknown genes with those deleted for known genes. The aims of this project are to explore the potential of this strategy for identifying gene function, and the use of NMR as a method for comprehensive analysis of the yeast metabolome. (Joint with grant 17880)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E17880 Comprehensive analysis of the yeast metabolome using NMR

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