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Development of micro-bioreactors for the study of the effect of physical biochemical and mechanical factors on cell functions
Reference
E18069
Principal Investigator / Supervisor
Professor Zhanfeng Cui
Co-Investigators /
Co-Supervisors
Dr Jill Urban
Institution
University of Oxford
Department
Engineering Science
Funding type
Research
Value (£)
288,564
Status
Completed
Type
Research Grant
Start date
03/03/2003
End date
02/03/2006
Duration
36 months
Abstract
The aim is to develop microbioreactors for cell and tissue culture using microfabrication and to use such micro bioreactors to study how extracellular parameters affect the physiology and functions of chondrocytes and ligament cells. The functions to be focused on the extracellular collagen accumulation and turnover, which has relevance to tissue engineering. The environmental factors will include interactions between culture medium composition (in relation to pH, oxygen tension) and mechanical conditions (hydrostatic pressure, flow and pressure pulsing). The results can guide the design and operation of tissue culture processes, particularly for cartilage and tendon and ligament tissue engineering. The developed microbioreactor can readily be used for the study of other cell types and engineered tissues.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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