BBSRC Portfolio Analyser
Award details
Biological activities of atropic adenovirus in optic nerve regeneration
Reference
E18035
Principal Investigator / Supervisor
Dr Ana Maria Gonzalez
Co-Investigators /
Co-Supervisors
Professor Andrew Baird
,
Professor Martin Berry
Institution
University of Birmingham
Department
Wolfson Research Laboratories
Funding type
Research
Value (£)
209,912
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
31/05/2007
Duration
37 months
Abstract
The physical placement of cation-condensed plasmids at the site of optic nerve injury using gene activated matrices (GAM) obviates any need for ligand-mediated gene delivery. But although the effects of GAM are sustained (more than3 mo), efficiency is low. Adenoviruses (AD) in GAM however increase efficiency but the GAM specificity for regenerating axons and repair cells is lost. To address this problem, we propose to test atropic AD particles. Neutralised AD will be placed in GAM and gene expression monitored in repair cells and in the retinal ganglion cells (RGC) that retrogradely transport particles from the GAM. The effects of the anti-apoptotic gene bc12 and neuron specific promoters in GAM will be evaluated on RGC survival.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search