Award details

Production and characterisation of the properties of an 'auroglycan' probe

Reference	E18028
Principal Investigator / Supervisor	Professor David Fernig
Co-Investigators / Co-Supervisors	Professor Mathias Brust, Professor Richard Nichols, Professor David Schiffrin
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	170,928
Status	Completed
Type	Research Grant
Start date	21/05/2003
End date	21/05/2006
Duration	36 months

Abstract

The glycosaminoglycan heparan sulfate (HS) binds, through specific sequences of saccharides, to a large number of extracellular regulatory proteins and so controls the activity of the latter. Short oligosaccharides representing the binding site of one or more regulatory proteins can readily be prepared from HS or heparin. It is proposed to develop a novel auroglycan probe that will be at least 1000-fold more sensitive than current methods of labelling HS. By virtue of its physical properties, this probe will allow the sensitive sequencing of oligosaccharides, the analysis of their cell biology and, eventually, of their molecular interactions. The techniques developed will be applicable to any oligosaccharide with a reducing end.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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