Award details

Supercritical fluid mixing of cells and polymers: a novel method of instant scaffold formation

Reference	E18018
Principal Investigator / Supervisor	Professor SM Howdle
Co-Investigators / Co-Supervisors	Professor Felicity Rose, Professor Kevin Shakesheff
Institution	University of Nottingham
Department	Sch of Chemistry
Funding type	Research
Value (£)	146,656
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	30/04/2005
Duration	24 months

Abstract

In pilot studies we have made a surprising finding that mammalian cells can survive within high pressure and supercritical CO2. This creates the possibility that polymers and cells can be co-processed to form instantly seeded porous scaffolds. We propose that high densities of viable human cells can be homogeneously dispersed throughout biodegradable scaffolds using our novel type of supercritical fluid processing. Our collaborative team will demonstrate the potential clinical relevance of this new bioengineering process through the formation of bone in standard models, including the subcutaneous and diffusions chamber models and the repair of critical bone defects, using supercritical fluid created osteoprogenitor and polymer composites laden with BMP-2 composites. (Joint with grant 18019)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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