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Protein-coated microcrystals: biomolecule stabilisation and applied biocatalysis
Reference
E17999
Principal Investigator / Supervisor
Dr Marie Claire Parker
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
School of Chemistry
Funding type
Research
Value (£)
135,940
Status
Completed
Type
Research Grant
Start date
01/11/2002
End date
01/11/2004
Duration
24 months
Abstract
Protein-coated microcrystals (PCMCs) are water-soluble micron-sized particles for use in applied biocatalysts. PCMCs have high catalytic activity, stability and could be utilised in biocatalyst screening. In this application, we wish to develop a one-pot optimised PCMC system for use in organic media, whereby a number of key properties crucial to optimum performance are incorporated in one preparation. The second objective is to investigate the operational stability of PCMSs in organic media and use their high water solubility to recover the protein and probe for protein modification. The process of PCMC formation and the nature of the protein-bound layer will be studied using high- speed imaging and Atomic Force microscopy (AFM).
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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