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Structurally-defined macromolecular prodrugs - synthesis and biological evaluation
Reference
E17987
Principal Investigator / Supervisor
Professor Alexander MacRobert
Co-Investigators /
Co-Supervisors
Dr Paul Samuel Dobbin
Institution
University College London
Department
The National Medical Laser Centre
Funding type
Research
Value (£)
194,176
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
15/02/2006
Duration
36 months
Abstract
To date, macromolecular prodrugs have been polydisperse but using recent advances in polymer chemistry we propose to synthesise macromolecular prodrugs with a defined structure and number of attached drug molecules. Our interest in prodrugs for photodynamic therapy has prompted us to develop a synthetic method for the generation of 5-aminolevulinic acid (ALA)-containing dendrimers which we have shown to enter tumour cells and release free ALA. We propose to perform an extensive biological evaluation of these and related dendrimers using fluorescence and chemical techniques. We will carry out in vitro studies to determine, in particular, (a) mechanism and rate of cellular uptake, ALA release and intracellular porphyrin generation.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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