Award details

Anomalous diffusion of proteins in cell membranes

Reference	E17847/2
Principal Investigator / Supervisor	Dr Andrew Reynolds
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Computational & Systems Biology
Funding type	Research
Value (£)	20,253
Status	Completed
Type	Research Grant
Start date	01/11/2004
End date	31/05/2006
Duration	19 months

Abstract

Anomalous diffusions is emerging as a key property in cell membrane dynamics because it is both a probe of membrane microstructure and because it is has a major influence on reaction kinetics within the membrane. A microscopic model for protein trajectories incorporating immobilising trapping-events and generalised Langevin dynamics, describing the motion of a Brownian particle acted upon by a stochastic force with long-range temporal correlation, will be formulated and examined in analytical studies. It is hypothesised that such a model predicts the coexistence of normal, anomalous and time- dependent restricted diffusion, non-Gaussian transport characteristics and the occurrence of transitions from anomalous to normal to anomalous diffusion, in accordance with experimental observations but in stark contrast with current modelling approaches.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E17847 Anomalous diffusion of proteins in cell membranes

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