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The exploitation of vanadium haloperoxidase enzymes in applied biocatalysis
Reference
E17619
Principal Investigator / Supervisor
Professor Jennifer Littlechild
Co-Investigators /
Co-Supervisors
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
209,076
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/05/2005
Duration
37 months
Abstract
1) To exploit the knowledge of the 3D structure of the dodecameric structure of the vanadium haloperoxidase solved in Exeter to optimise its use in biological catalysis 2) To optimise an over- expression system for the enzyme so that large amounts of the enzyme and mutant enzymes can be produced with ease 3) To design and characterise site-specific mutants of the enzyme with altered properties for halide specificity and substrate reactivity for halogenation, sulfoxidation and potential expoidation reactions.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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