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Regulation of stem cell differentiation for the tissue engineering of cartilage

Reference	E17305
Principal Investigator / Supervisor	Professor Anthony Hollander
Co-Investigators / Co-Supervisors	Dr Michael Billingham, Professor Jeffery Holly, Dr Wael Kafienah, Dr Mark Perry
Institution	University of Bristol
Department	Department of Academic Rheumatology
Funding type	Research
Value (£)	260,420
Status	Completed
Type	Research Grant
Start date	01/09/2002
End date	31/12/2005
Duration	40 months

Abstract

We will investigate the regulation of stem cell differentiation to chondrocytes by natural and synthetic ligands of nuclear receptors. Stem cells from bone marrow and synovial membrane will be cultured in monolayer or aggregate culture. We will carry out a comprehensive analysis of the expression of various nuclear receptors at different time points in culture in relation to maturation markers. Natural or synthetic ligands for some of these receptors will be used to regulate the differentiation process. The resulting cells will be used to engineer cartilage on polyglycolic acid scaffolds and the final tissue will be assessed for cartilage quality. Finally, we will attempt to generate chondrocytes by expansion and differentiation of pluripotent stem cells from umbilical cord blood, using our selected ligands.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Engineering & Biological System Committee (EBL) [2000-2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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