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Characterisation of a specific articular cartilage progenitor cell
Reference
E17303
Principal Investigator / Supervisor
Professor Charles Archer
Co-Investigators /
Co-Supervisors
Dr Gary Dowthwaite
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
203,968
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/04/2005
Duration
36 months
Abstract
We have isolated a cell from the surface of articular cartilage that has the properties of a progenitor:stem cell. We wish to further characterise this cell in terms of its requirements for growth factor:morphogenes for it to progress through its differentiative repertoire, particular attention being focussed on the expression of cell fate selection genes Notch 1 and its ligands Delta and Jagged. We will determine whether the progenitor-like properties are lost with age and if this is the case whether they can be rescued by transfection techniques. Finally, we will gain insights into the role of the EDA variant of fibronectin that is selectively synthesised at the articular surface in regard to possible mitogenic activity.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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