Award details

Controlled delivery of biomacromolecular therapeutics from biocompatible polymer films

Reference	E17296
Principal Investigator / Supervisor	Professor Jian Lu
Co-Investigators / Co-Supervisors	Dr Cathy Holt
Institution	The University of Manchester
Department	Physics and Astronomy
Funding type	Research
Value (£)	162,340
Status	Completed
Type	Research Grant
Start date	01/12/2002
End date	31/03/2006
Duration	40 months

Abstract

Biomacromolecules such as heparin, oligonucleotides (antisense), antibody fragments (abciximab) and growth factors are of potential benefit in reducing in-stent restenosis if they could be delivered locally to the implant site. Many of these drugs are negatively charged and it is possible to control the loading and release via their interaction with phosphorylcholine (PC) polymers containing positively charged groups. This work aims to explore the routes and conditions for controlled loading and release for these therapeutic biomacromolecules from the PC polymer films by means of electrostatic interaction combined with the adjustment of the nano-structural domains within the PC films, and to assess the bioactivities of the drugs released and the angiogenic behaviour of the modified surfaces to cell growth. The project represents a true interdisciplinary collaboration to tackle in-stent restenosis.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	Industrial Partnership Award (IPA)

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search