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Targeted delivery of gene-based medicines to vascular endothelium
Reference
E17190
Principal Investigator / Supervisor
Professor Andrew Baker
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Medicine (Western Infirmary)
Funding type
Research
Value (£)
139,333
Status
Completed
Type
Research Grant
Start date
01/05/2002
End date
30/04/2005
Duration
36 months
Abstract
The vascular endothelium plays a pivotal role in homeostasis and development of diverse diseases. Gene-based medicines offer an unprecedented opportunity to treat human disease. However, gene delivery to vascular endothelial cells in vivo is extremely poor using conventional vector systems. Here, we propose to develop and optimise viral gene delivery systems for vascular endothelium through modification of viral coat proteins (for both adenoviral and adeno-associated viral vectors) and through genetic incorporation of endothelium-restricted transcription cassettes. This combined approach will enhance the efficiency and selectivity of gene delivery to endothelium in vivo for diverse applications including cardiovascular disease and cancer.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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