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Segregation domains in T cell:APC contact interfaces
Reference
E17188
Principal Investigator / Supervisor
Professor Nigel Burroughs
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Mathematics
Funding type
Research
Value (£)
157,156
Status
Completed
Type
Research Grant
Start date
31/03/2003
End date
31/03/2006
Duration
36 months
Abstract
A model of molecule movement and segregation in cell:cell interfaces is proposed, incorporating reaction diffusion equations, thermodynamics, thermal fluctuations and cell elasticity. Extracellular domain size differences affect molecule localisation by feedback through contact interface depth, depth heterogeneity in the interface being driven by a bond energy dependence on bond stretching and compression. A thorough analysis of segregation driven by bond length differences is proposed examining the interplay of signalling and physical processes that underlie the molecule segregation (differential enrichment) observed in T-cell:APC interactions, leading to a kinetic and steady state comparison with experiment and mechanism identification.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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