Award details

Rapid screening of heparan sulphate-protein interactions

Reference	E16779
Principal Investigator / Supervisor	Professor Jeremy Turnbull
Co-Investigators / Co-Supervisors	Dr Andrew Powell
Institution	University of Birmingham
Department	Sch of Geography, Earth & Env Sciences
Funding type	Research
Value (£)	104,884
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	01/12/2003
Duration	24 months

Abstract

We propose to establish an array strategy for rapid screening of the interactions of heparan sulphate (HS) saccharides with proteins, peptides and cells. HS polysaccharides are multifunctional regulators in which specific protein-binding sequences determine selective regulatory properties. These interactions impinge on many biological systems and disease processes, and represent novel potential therapeutic targets. Progress in this field requires new methods for identifying bioactive saccharides. The array strategy under development represents a powerful new technology for studying HS-protein interactions, and trials will be conducted on anti-HS antibodies, growth factors/receptors and pathogen surface proteins.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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