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Novel application of the Pseudomonas flourescens biofilm cellulose-matrix as scaffold material in tissue engineering
Reference
E16689
Principal Investigator / Supervisor
Professor Chris Leaver
Co-Investigators /
Co-Supervisors
Professor Zhanfeng Cui
,
Dr Andrew Spiers
,
Professor James Triffitt
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
99,624
Status
Completed
Type
Research Grant
Start date
25/11/2002
End date
24/11/2004
Duration
24 months
Abstract
Pseudomonas fluorescens produces a biofilm in which the major structural component is an extracellular cellulose- like polymer (CLP). The ultrastructure of the biofilm and novel aspects of CLP suggest that both the biofilm matrix (skeleton) and purified CLP have potential applications as scaffold material for tissue engineering. We propose (i) to chemically characterise purified CLP; (ii) to produce purified biofilm matrix and determine its physical characteristics; and (iii) to test the ability of bone stem cells to invade and colonise biofilm matrix scaffolds.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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