Award details

Development of a generic platform for the high throughput discovery of specific kinase substrates

Reference	E16621
Principal Investigator / Supervisor	Dr Joachim Steinke
Co-Investigators / Co-Supervisors	Dr David Mann, Professor Ramon Vilar Compte
Institution	Imperial College London
Department	Chemistry
Funding type	Research
Value (£)	354,616
Status	Completed
Type	Research Grant
Start date	11/02/2002
End date	10/07/2006
Duration	53 months

Abstract

As we enter the post-genomic age, the major challenges facing biologists revolve around the characterisation of the function and regulation of the cellular proteome. Protein function is often controlled by phosphorylation/dephosphorylation. In this proposal we aim to establish a platform for the analysis of the phosphoproteome using a combination of biological and chemical techniques. Our interdisciplinary approach will generate novel, highly specific, supramolecular ligands for bioseparations that will be scaleable and will, with suitable modifications, be generally applicable to a wide range of proteomic separations. Our platform will be automated and combined with mass spectrometry and bioinformatics to facilitate high-throughput analyses.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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