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Development of enantioselective amine oxidases for application in the deracemisation of racemic chiral amines
Reference
E16616
Principal Investigator / Supervisor
Professor Nicholas Turner
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
124,020
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2004
Duration
24 months
Abstract
The aim of this project is to develop a novel, and generally applicable, method for the synthesis of a wide range of optically pure chiral amines. The approach to be adopted involves the deracemisation of racemic amines by using an enantioselective amine oxidase enzyme in combination with a non-selective chemical reducing agent. An important aspect of the project will be the identification and characterisation of novel amine oxidases through in vitro evolution methods. Rapid high-throughput screening protocols will be developed for the selection of variants with the desired characteristics. These new enzymes will be characterised and applied to the deracemisation of chiral amines on preparative scale.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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