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Molecular evolution approach for the affinity maturation of anti-microcystin antibodies from phage display libraries

Reference	E16608
Principal Investigator / Supervisor	Professor Andrew Porter
Co-Investigators / Co-Supervisors	Professor Linda Lawton
Institution	University of Aberdeen
Department	School of Medical Sciences
Funding type	Research
Value (£)	216,316
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	01/12/2004
Duration	36 months

Abstract

Cyanobacteria commonly form blooms in fresh water including recreational and drinking water reservoirs. Some species are capable of producing toxins, including microcystins which are potent hepatotoxins implicated in the poisoning of humans and animals world-wide. The monitoring of microcystins currently involves off-site processing and analysis of samples which can be time consuming and expensive. In this project, we will employ a number of molecular evolution strategies to affinity mature a panel of anti-microcystin antibodies selected from naive (non- immunised) phage display libraries. The resulting antibodies will then be used to develop a highly sensitive assay for rapid on-site detection of microcystins.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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