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A simple and economic process for viral vaccines: process synthesis and modelling of in vitro self-assembly
Reference
E16515
Principal Investigator / Supervisor
Dr Robert Falconer
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemical Engineering and Biotechnology
Funding type
Research
Value (£)
212,892
Status
Completed
Type
Research Grant
Start date
15/04/2002
End date
14/12/2005
Duration
44 months
Abstract
We will develop an economic and simple process for the production of virus-like particles (VLPs) following soluble expression in E. coli. Human papillomavirus type 16 (HPV16) is selected for this study because recent published work has demonstrated a high yield of purified VLPs in the laboratory. HPV16 is also clinically relevant, as it is implicated in the majority of cervical cancer deaths. We will use the developed process to produce enough protein for a detailed investigation of in vitro self-assembly. This will enable, for the first time, experimental testing of an existing statistical mechanical model of VLP self-assembly, with the aim of establishing a new framework for mathematically modelling viral self-assembly.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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