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Regeneration of bone revision total hip arthroplasty using tissue engineering techniques

Reference	E16046
Principal Investigator / Supervisor	Professor Jia Hua
Co-Investigators / Co-Supervisors	Professor Gordon Blunn, Professor Allen Goodship, Miss Sarah Muirhead-Allwood
Institution	University College London
Department	Medical Physics and Biomedical Eng
Funding type	Research
Value (£)	243,400
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	30/06/2005
Duration	42 months

Abstract

Failure of total hip replacement (THR) due to osteolysis leads to a 9 percent revision rate in UK. Revision of THRs have worse results that primary THRs due to poor fixation caused by reduced bone stock. Regeneration of bone is critical. The amount of bone regenerated using current allograft techniques is limited and success is variable. Tissue engineering techniques are potentially able to regenerate bone. It is hypothesised that autogenic mesenchymal stem cells, mixed with a porous hydroxyapatite carrier and delivered back into the same patient can generate new bone in revision THR procedures leading to improved fixation. Bone regeneration and fixation will be assessed and compared with groups where allograft bone has been used.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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