Award details

Nanowriting and nanomanipulation of biomolecules with a micropipette

Reference	E15801
Principal Investigator / Supervisor	Professor David Klenerman
Co-Investigators / Co-Supervisors	Professor Chris Abell, Professor Yuri Korchev
Institution	University of Cambridge
Department	Chemistry
Funding type	Research
Value (£)	394,924
Status	Completed
Type	Research Grant
Start date	01/11/2001
End date	30/04/2005
Duration	42 months

Abstract

We propose to develop our work on scanning ion conductance microscopy combined with fluorescence microscopy and use a micropipette for local, controlled delivery of biological molecules to a surface in solution. The pipettes have 50-200 nm diameters opening up the possibility of writing at sub-micron resolution. We will optimise the feature size and explore multiple applications by use of multi-barrel pipettes. We will also explore the possibility of performing single molecule manipulations and follow the process in situ using single molecule fluorescence spectroscopy. We will then explore the manipulation of biological materials and the creation of novel nanostructures and arrays using this new method.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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