Award details

Modelling T cell activation

Reference	E15784
Principal Investigator / Supervisor	Professor Andrew George
Co-Investigators / Co-Supervisors	Professor Jaroslav Stark
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	170,496
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

The ability of T cells to recognise a foreign antigen is central to the immune response. This recognition involves the T cell receptor (TCR) binding to a complex formed by the molecules of the MHC and antigenic peptide. The T cell manages to be both specific in its response, as well as sensitive; recognising as few as 10 specific peptide-MHC complexes amongst 1 million to 10 million irrelevant ligands. Using a computer model we have previously shown that this ability to be highly specific and highly sensitive is a result in part of positive and negative cross talk between TCR. We propose to further investigate the nature of T cell recognition, in particular exploring how null ligands affect the sensitivity of the response and how the thymus shapes the TCR repertoire.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search