Award details

Creation of a nanoparticle biosensor for multiplex single nucleotide polymorphism analysis

Reference	E15769
Principal Investigator / Supervisor	Professor Duncan Graham
Co-Investigators / Co-Supervisors	Professor William Smith
Institution	University of Strathclyde
Department	Pure and Applied Chemistry
Funding type	Research
Value (£)	175,816
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	01/01/2005
Duration	36 months

Abstract

Creation of a biosensor based on formation of 3D silver nanoparticle clusters is proposed. Individual nanoparticles are loaded with specific oligonucleotide probes that respond to the target sequence of DNA to produce a nanoscale cluster and switch on the detection technique of surfaced enhanced resonance Raman scattering (SERRS). Thus, the biosensor response is observed by the appearance of SERRS signals that are specific to the sequence sensed. SERRS can identify mixtures without separation and as such will allow one pot multiplexing. This biosensor will be used in a high throughput automated format for single nucleotide polymorphism analysis based on data released from the human genome and related projects.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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