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Award details
Characterisation and engineering of a newly identified Ig-binding motif
Reference
E15767
Principal Investigator / Supervisor
Professor Michael Gore
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
180,528
Status
Completed
Type
Research Grant
Start date
01/03/2002
End date
30/06/2005
Duration
40 months
Abstract
The aim of the project is to produce new immunoglobulin- binding proteins to furnish the existing multi-million pound bio-medical industry with therapeutic, diagnostic and preparative affinity ligands. Recent X-ray crystallographic data have characterised a new, second Ig-binding site on each of the Ig-domains of Protein L from Peptostreptococcus magnus. This second binding site interfaces with light chains in a novel manner to the previously characterised binding site and presents a unique opportunity to produce a novel type of binding protein for Igs. The project will be aimed at the manipulation of this binding interaction to produce monovalent binding domains for lambda chains and bivalent domains that will complex with both kappa and lambda light chains to produce a universal Ig-binding protein.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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