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The use of bacterial chemotaxis and engineered chemoreceptors to detect pollutants

Reference	E15526
Principal Investigator / Supervisor	Professor Judith Armitage
Co-Investigators / Co-Supervisors	Professor C Knowles
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	257,588
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	30/09/2004
Duration	36 months

Abstract

Extracellular chemoeffector sensing controls the switching of bacterial flagellar motors. Chemoeffectors vary between species, but all use a common cytoplasmic pathway. Species important in bioremediation sense pollutants, with sensory thresholds as low as nM, and a range of over 7 orders of magnitude. We intend to: (i) characterise the responses of a range of laboratory stains and species isolated from contaminated sites to a range of biodegradable pollutants; (ii) examine the effects on those responses of the local environment; (iii) test the effects of selected bioavailability constraints; (iv) clone receptor genes for specific chemoeffectors into model strains; and (v) develop chimeric response regulators to drive alternative detectors.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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