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Synthesis hybridisation and patterning of DNA at silicon surfaces

Reference	E15128
Principal Investigator / Supervisor	Professor Andrew Houlton
Co-Investigators / Co-Supervisors	Professor Bernard Connolly, Dr Benjamin Horrocks
Institution	Newcastle University
Department	School of Chemistry
Funding type	Research
Value (£)	209,156
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

Hydrogen-terminated silicon surfaces formed on etching with aqueous fluoride are an integral step in the fabrication of semiconductor devices. The surface generated undergoes reaction with molecular functional groups to form covalently-modified silicon surfaces. This chemistry differs from typical methods for derivatizing silicon as attachment is to surface silicon and not to the insulating oxide. It is intended to use this chemistry to synthesise covalently bound oligonucleotides at silicon surfaces. The capabilities of these tethered oligonucleotides to undergo hybridisation with complementary sequences using redox- and fluorescent-labelled derivatives will then be evaluated. Finally it is planned to fabricate patterned surfaces and investigate enzymatic processing of the DNA on the surface.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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