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Mucoadhesive colon-specific drug delivery systems
Reference
E15109
Principal Investigator / Supervisor
Dr Christopher Jackson
Co-Investigators /
Co-Supervisors
Professor John Smart
Institution
University of Portsmouth
Department
Pharmacy Biomedical Sciences Duplicate
Funding type
Research
Value (£)
98,084
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2003
Duration
24 months
Abstract
The research is aimed towards the evaluation of an orally-administered drug delivery system, which will be mucoadhesive, colon-specific and microparticulate. The system will exploit two features of the gastrointestinal tract for optimal performance: the increased lumenal pH from the stomach to the large intestine and the azo- reducing environment of the colon. An important feature of the work will be the study, via radiolabelled co- monomer units, of the post-ingestion biodistribution of the polymer using an in vivo model. Successful completion of the project should establish a universally applicable, site-specific microparticulate drug delivery system capable of reaching the colon via the oral route.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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