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Engineering functional liver tissue in vitro: exploiting the link between cell communication and gene expression
Reference
E15105
Principal Investigator / Supervisor
Professor Kevin Shakesheff
Co-Investigators /
Co-Supervisors
Dr Andrew Bennett
,
Dr Rena Bhandari
,
Dr Jeff Fry
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
246,596
Status
Completed
Type
Research Grant
Start date
20/04/2001
End date
20/04/2004
Duration
36 months
Abstract
We propose that two-way communication between hepatocytes and stellate cells can be exploited in the engineering of long-term functional liver tissue in vitro for xenobiotic metabolism screening and tissue engineering applications. Building on proof-of-concept data from our laboratories, it will be possible to elucidate the roles of soluble mediators, extracellular matrix signals and cell-to-cell receptor-mediated contacts in the control of gene expression of defined cytochrome P450 (CYP) enzymes. This will provide new mechanisms of promoting the formation of stable stellate-hepatocyte complexes that form rapidly and retain liver-specific activities indefinitely.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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