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Smart hyperbranched polymers for protein purification
Reference
E14976
Principal Investigator / Supervisor
Professor Stephen Rimmer
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Chemistry
Funding type
Research
Value (£)
173,808
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
01/08/2004
Duration
36 months
Abstract
Highly branched (hyperbranched) polymers, which are water-soluble at low temperatures but are water- insoluble at elevated temperatures will be synthesized. Imidazole ligands resident at the chain ends will be used to complex various natural and recombinant proteins. The polymer/protein complex will then be used to extract the target protein from solution, following confirmational collapse of the polymer. Thus we will prepare and examine new materials designed for protein extraction and purification. The affinity of the new materials for various proteins will be examined as will their resistance to non-specific adsorbance of non- target proteins. Studies of the engineering parameters of the process will also be undertaken.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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