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Award details
Mechanisms kinetics of membrane transport and structure-activity relationships of membrane translocating peptides
Reference
E14784
Principal Investigator / Supervisor
Professor Anthony Smith
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Pharmacy and Pharmacology
Funding type
Research
Value (£)
166,994
Status
Completed
Type
Research Grant
Start date
01/12/2000
End date
31/05/2004
Duration
42 months
Abstract
Membrane translocating peptides (MTP) appear to cross biological membranes by passive processes and can be used to deliver active polypeptides to intracellular locations. This project will investigate the mechanisms of action of known MTPs, and quantify the kinetics of mass transport at the cellular and tissue level. Emphasis will be placed on determining the common structural requirements for translocation of existing MTPs, and examining the effects of polypeptide payloads on transport kinetics. Structure-activity studies will be carried out using a random mutagenesis strategy, with a view to designing optimal features of MTPs. The project will provide a fundamental evaluation of MTPs for delivery of therapeutic peptides.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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