Award details

Biomembrane force probe for mapping energy landscapes in protein interactions and folding

Reference	E14767
Principal Investigator / Supervisor	Professor Philip Williams
Co-Investigators / Co-Supervisors	Professor Stephanie Allen, Professor Saul Tendler
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	229,428
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2004
Duration	36 months

Abstract

This application seeks to extend our knowledge of protein folding mechanisms by developing the United Kingdom's first biomembrane force probe (BFP) for dynamic force spectroscopy to be used alongside atomic force microscopy and computer simulations in the study of inter- and intra-molecular energy landscapes. In collaboration with recognised BFP experts, a BFP will be constructed for high-resolution force studies of protein interactions and unfolding experiments. Investigations of molecular interactions and comparison of results with other studies and methods will lead the development of the technique. The system will be used to study the kinetics and energetics of folding of protein fold motifs, in particular the helix, coiled-coil interactions and the beta-sheet.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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