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A tissue engineering approach to corticospinal tract repair
Reference
E14683
Principal Investigator / Supervisor
Professor Kevin Shakesheff
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
124,472
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
01/07/2003
Duration
24 months
Abstract
Recent findings provide evidence that transplanting olfactory ensheathing cells (OECs) into the corticospinal tract (CST) induces axon regeneration and function recovery. A major challenge remains to translate these exciting findings on small regions of damaged CST into human medical interventions that require a larger axonal regeneration response. In this proposal researchers at Nottingham will carry forward work on OECs, in collaboration with NIMR, with the aim of determining how OECs can be stimulated to form 'regenerative units' within hydrogel scaffolds. This will require a detailed understanding of the mechanisms of self- assembly of OECs into complex architectures in which two cell subpopulations 'phase separate'. This knowledge will be exploited to generate appropriate receptor-mediated OEC migration and cortical neuron regeneration.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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