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Strucure of DNA-copolymer colloidal complexes

Reference	E14660
Principal Investigator / Supervisor	Professor Snjezana Stolnik-Trenkic
Co-Investigators / Co-Supervisors	Professor Steven Armes, Professor Clive Washington
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	2,497
Status	Completed
Type	Research Grant
Start date	20/09/2001
End date	20/09/2002
Duration	12 months

Abstract

We propose to use SANS to obtain high resolution structural information on the structure of the colloidal complexes formed between DNA and cationic copolymers, and to assess the effects of the introduction of other noninteracting blocks into the polymer. The structure of the DNA complexes with three structurally related copolymers based on poly(amine methacrylates) and poly (ethylene oxide), and the parent homopolymer, will be studied. The resulting structural data will be correlated with the physicochemical and biological properties (e.g. the cell transfection ability) of the systems to explore the structure-activity relationships. We believe that this is essential for rational design of complexing polymers for gene therapy.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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