Award details

Realising a qualitative increase in the capacity of proteomics by statistical image analysis of 2D electrophoresis gels

Reference	E14651
Principal Investigator / Supervisor	Dr James Graham
Co-Investigators / Co-Supervisors	Dr Patrick Courtney
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	197,912
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2004
Duration	36 months

Abstract

The analysis of 2D electrophoresis gels is likely to be a key technique in proteomics for the foreseeable future. The capacity of information generated from gel images is limited by the highly interactive analysis that is required in using the current generation of image analysis systems. By taking a statistical, model- based approach we will develop a new generation of image analysis tools which will deliver a qualitative improvement in performance. Interactive analysis of images will be replaced by interactive training to generate a statistical model of the control images. This will then be used to deliver automatic reading of subsequent images and to provide a statistical basis for characterising differences arising in modified subjects.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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