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Award details
Development of elementary modes analysis for metabolic engineering applications
Reference
E14591
Principal Investigator / Supervisor
Professor David Fell
Co-Investigators /
Co-Supervisors
Institution
Oxford Brookes University
Department
Faculty of Health and Life Sciences
Funding type
Research
Value (£)
136,912
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
31/07/2004
Duration
43 months
Abstract
Elementary modes analysis is a technique for finding all the functional capabilities of a metabolic network, and is therefore a useful tool for designing strategies for the rational modification of metabolism; metabolic engineering. This project will extend the scope of the analysis by eliminating the need to classify reactions rigidly into bi-directional or unidirectional. Techniques for decomposing observed flux patterns in metabolic networks into constituent modes shall be developed to guide choice of metabolic engineering strategies. New software will be written to perform the modified analyses, and will be tested on applications such as polyhydroxybutyrate synthesis in yeast and synthesis of clavulanic acid and polyketides.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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