Award details

Systems of stochastic and deterministic molecular circadian oscillators

Reference	E14035
Principal Investigator / Supervisor	Professor David Rand
Co-Investigators / Co-Supervisors	Professor Charalambos Kyriacou, Dr Patricia Lakin-Thomas, Professor Andrew Millar
Institution	University of Warwick
Department	Mathematics
Funding type	Research
Value (£)	143,804
Status	Completed
Type	Research Grant
Start date	15/05/2001
End date	15/05/2004
Duration	36 months

Abstract

This is the theoretical part of a project bringing together experimental and theoretical groups. It is concerned with a detailed study of deterministic and stochastic models of circadian oscillators at the molecular level. There will be a strong interaction with experiment in terms of the current understanding of the molecular components, comparison with contemporary data and the development of new experiments. We will consider when coupling between pairs of oscillators exists, develop methods to measure its strength and address the question of how coupled systems may allow circadian rhythms to track both dawn and dusk. The final part, which has high priority, will analyse large systems of coupled oscillators, such as those of the mammalian SCN. These are mathematically very challenging and of increasing biological importance.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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